Scientist II
Company: Frederick National Laboratory for Cancer Research
Location: Bethesda
Posted on: January 12, 2021
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Job Description:
Scientist IIJob ID: req1537Employee Type: exempt
full-timeFacility: NIHLocation: NIH Campus 9000 Rockville Pike,
Bethesda, MD 20892 USAThe Frederick National Laboratory is a
Federally Funded Research and Development Center (FFRDC) sponsored
by the National Cancer Institute (NCI) and operated by Leidos
Biomedical Research, Inc. The lab addresses some of the most urgent
and intractable problems in the biomedical sciences in cancer and
AIDS, drug development and first-in-human clinical trials,
applications of nanotechnology in medicine, and rapid response to
emerging threats of infectious diseases. Our core values of
accountability, compassion, collaboration, dedication, integrity,
and versatility serve as a guidepost for how we do our work every
day in serving the public---s interest. Position Overview:PROGRAM
DESCRIPTIONThe National Clinical Target Validation Laboratory
(NCTVL) serves as a clinical pharmacodynamic biomarker validation
and testing center for the NCI---s Division of Cancer Treatment &
Diagnosis (DCTD) and is a key component in the clinical
pharmacodynamics (PD) program at the Frederick National Laboratory
for Cancer Research. NCTVL works closely to convert newly developed
and validated assays of biomarkers of drug mechanism of action into
clinical assays, and works closely with NCI clinicians and
investigators to use the validated clinical assays to analyze
patient specimens from early clinical trials and report assay
results to inform the trials and confirm drug mechanisms of action
(MOA) of the investigational agents in patients. KEY
ROLES/RESPONSIBILITIESPlan, conduct, analyze and report on PD
biomarker assessment of biopsy specimens using imaging technology
platforms and instrumentations in the support of early clinical
trials and fitness-for-purpose non-clinical studies (current
technology platforms include quantitative immunofluorescence
microscopy, imaging mass cytometry, and immunohistochemistry with
digital image acquisition and analyses) Work closely with assay
development scientists in PD assay transfer, validation and
harmonization activitiesLead NCTVL in PD testing support of
preclinical and clinical studies including supervising research
associates and data analysis and reportingAssist lab director in
managing lab R & D projects, QA, QC and reagent manufacturingBASIC
QUALIFICATIONSPossession of PhD degree from an accredited
college/university according to the Council for Higher Education
Accreditation (CHEA) in a biochemistry, genetics, pharmacology,
pathology or related field. Foreign degrees must be evaluated for
U.S. equivalencyIn addition to educational requirements, at least 2
years of postdoctoral experience in cancer diagnostics,
therapeutics, drug development, pharmacology, pharmaceutics, or
other human disease related preclinical/clinical R & D
projectsExperience using imaging techniques and technologies to
quantify (measure) drug effects as part of an investigation into
drug pharmacology and/or mechanism of action (MOA)Must be able to
obtain and maintain a security clearancePREFERRED
QUALIFICATIONSImmunofluorescent microscopy-based biomarker research
and development experienceImmunofluorescent microscopy-based
laboratory work on drug mechanism of action and/or measurement of
drug effects in tissue specimensWorking knowledge and laboratory
experience in anti-cancer drug mechanisms of action, including DNA
repair, apoptosis and other cell death related pathways, or
immuno-oncology related biomarker discovery and development,
preferably with hands-on projectsPreclinical and clinical specimen
process and testing experienceExperience with assay transfer &
validation, critical reagent production/diagnostic reagent
manufacturingSuccessful working history in matrix organization for
clinical lab support programExperience using clinical assays within
a regulated environment (e.g., IND studies, CLIA, GLP/GMP
environments)JOB HAZARDSThis position is subject to working with or
have potential for exposure to animal(s) and/or animal
material(s)This position is subject to working with or have
potential for exposure to infectious material, requiring medical
clearance and immunizationsEqual Opportunity Employer (EOE) -
Minority/Female/Disabled/Veteran (M/F/D/V) - Drug Free Workplace
(DFW)readytowork
Keywords: Frederick National Laboratory for Cancer Research, Bethesda , Scientist II, Other , Bethesda, Maryland
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