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Scientist II

Company: Frederick National Laboratory for Cancer Research
Location: Bethesda
Posted on: January 12, 2021

Job Description:

Scientist IIJob ID: req1537Employee Type: exempt full-timeFacility: NIHLocation: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USAThe Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public---s interest. Position Overview:PROGRAM DESCRIPTIONThe National Clinical Target Validation Laboratory (NCTVL) serves as a clinical pharmacodynamic biomarker validation and testing center for the NCI---s Division of Cancer Treatment & Diagnosis (DCTD) and is a key component in the clinical pharmacodynamics (PD) program at the Frederick National Laboratory for Cancer Research. NCTVL works closely to convert newly developed and validated assays of biomarkers of drug mechanism of action into clinical assays, and works closely with NCI clinicians and investigators to use the validated clinical assays to analyze patient specimens from early clinical trials and report assay results to inform the trials and confirm drug mechanisms of action (MOA) of the investigational agents in patients. KEY ROLES/RESPONSIBILITIESPlan, conduct, analyze and report on PD biomarker assessment of biopsy specimens using imaging technology platforms and instrumentations in the support of early clinical trials and fitness-for-purpose non-clinical studies (current technology platforms include quantitative immunofluorescence microscopy, imaging mass cytometry, and immunohistochemistry with digital image acquisition and analyses) Work closely with assay development scientists in PD assay transfer, validation and harmonization activitiesLead NCTVL in PD testing support of preclinical and clinical studies including supervising research associates and data analysis and reportingAssist lab director in managing lab R & D projects, QA, QC and reagent manufacturingBASIC QUALIFICATIONSPossession of PhD degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in a biochemistry, genetics, pharmacology, pathology or related field. Foreign degrees must be evaluated for U.S. equivalencyIn addition to educational requirements, at least 2 years of postdoctoral experience in cancer diagnostics, therapeutics, drug development, pharmacology, pharmaceutics, or other human disease related preclinical/clinical R & D projectsExperience using imaging techniques and technologies to quantify (measure) drug effects as part of an investigation into drug pharmacology and/or mechanism of action (MOA)Must be able to obtain and maintain a security clearancePREFERRED QUALIFICATIONSImmunofluorescent microscopy-based biomarker research and development experienceImmunofluorescent microscopy-based laboratory work on drug mechanism of action and/or measurement of drug effects in tissue specimensWorking knowledge and laboratory experience in anti-cancer drug mechanisms of action, including DNA repair, apoptosis and other cell death related pathways, or immuno-oncology related biomarker discovery and development, preferably with hands-on projectsPreclinical and clinical specimen process and testing experienceExperience with assay transfer & validation, critical reagent production/diagnostic reagent manufacturingSuccessful working history in matrix organization for clinical lab support programExperience using clinical assays within a regulated environment (e.g., IND studies, CLIA, GLP/GMP environments)JOB HAZARDSThis position is subject to working with or have potential for exposure to animal(s) and/or animal material(s)This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizationsEqual Opportunity Employer (EOE) - Minority/Female/Disabled/Veteran (M/F/D/V) - Drug Free Workplace (DFW)readytowork

Keywords: Frederick National Laboratory for Cancer Research, Bethesda , Scientist II, Other , Bethesda, Maryland

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